Maraciclatide is for investigational use only and is not approved by the FDA or UK and European regulatory authorities.
Breakthrough molecular Imaging technology
99mTc-maraciclatide is a radio-labelled tracer containing the RGD tripeptide motif (Arg-Gly-Asp) which binds with high affinity to αvβ3 integrin1, a cell-adhesion molecule which is up-regulated on activated vascular endothelial cells, activated
macrophages and osteoclasts2. 99mTc-maraciclatide uptake in the joints has been shown to be highly
correlated with Power Doppler Ultrasound (PDUS) in an initial proof of concept study in 5 patients3
and subsequently in a study involving 50 patients4,5.
99mTc-maraciclatide planar imaging has the capacity to image the whole body, highlighting total
synovial inflammatory load in a 20 minute acquisition without requiring the rheumatologist’s time.
99mTc-maraciclatide images are easy to interpret to the untrained observer and we are exploring how images might inform a patient’s view of their condition and treatment.
1 Ebenhan T, Kleynhans J, Zeevaart JR, et al. Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents. Eur J Nucl Med Mol Imaging 2020; https://doi.org/10.1007/s00259-020-04975-9
2 Eliceiri BP, Cheresh DA. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999;103(9):1227-30.
3 Attipoe L, Chaabo K, Wajed J, et al. Imaging neoangiogenesis in rheumatoid arthritis (INIRA): whole-body synovial uptake of a 99mTc-labelled RGD peptide is highly correlated with power Doppler ultrasound. Ann Rheum Dis 2020;79:1254-1255.
4 Attipoe L, Garrood T, Subesinghe S, et al. Imaging Neoangiogenesis in Rheumatoid Arthritis (INIRA): Whole-Body Synovial Uptake of a 99mTc-Labelled RGD Peptide Is Highly Correlated with Power Doppler Ultrasound [abstract]. Arthritis Rheumatol 2019;71(suppl 10).
5 Attipoe L, Subesinghe S, Blanco-Gil C, et al. Imaging neoangiogenesis in rheumatoid arthritis (INIRA): whole-body synovial uptake of a 99mTc-labelled RGD peptide is highly correlated with power Doppler ultrasound. Ann Rheum Dis 2020;79, supplement 1:110.