Healthcare Professionals

Maraciclatide is for investigational use only and is not approved by the FDA or UK and European regulatory authorities.

Breakthrough molecular Imaging technology

Images courtesy of Dr Toby Garrood, Guy’s Hospital, London

99mTc-maraciclatide is a radio-labelled tracer containing the RGD tripeptide motif (Arg-Gly-Asp) which binds with high affinity to αvβ3 integrin1, a cell-adhesion molecule which is up-regulated on activated vascular endothelial cells, activated macrophages and osteoclasts2. 99mTc-maraciclatide uptake in the joints has been shown to be highly correlated with Power Doppler Ultrasound (PDUS) in an initial proof of concept study in 5 patients3 and subsequently in a study involving 50 patients4,5.

99mTc-maraciclatide planar imaging has the capacity to image the whole body, highlighting total synovial inflammatory load in a 20 minute acquisition without requiring the rheumatologist’s time.

99mTc-maraciclatide images are easy to interpret to the untrained observer and we are exploring how images might inform a patient’s view of their condition and treatment.

References

1 Ebenhan T, Kleynhans J, Zeevaart JR, et al. Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents. Eur J Nucl Med Mol Imaging 2020; https://doi.org/10.1007/s00259-020-04975-9

2 Eliceiri BP, Cheresh DA. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999;103(9):1227-30.

3 Attipoe L, Chaabo K, Wajed J, et al. Imaging neoangiogenesis in rheumatoid arthritis (INIRA): whole-body synovial uptake of a 99mTc-labelled RGD peptide is highly correlated with power Doppler ultrasound. Ann Rheum Dis 2020;79:1254-1255.

4 Attipoe L, Garrood T, Subesinghe S, et al. Imaging Neoangiogenesis in Rheumatoid Arthritis (INIRA): Whole-Body Synovial Uptake of a 99mTc-Labelled RGD Peptide Is Highly Correlated with Power Doppler Ultrasound [abstract]. Arthritis Rheumatol 2019;71(suppl 10).

5 Attipoe L, Subesinghe S, Blanco-Gil C, et al. Imaging neoangiogenesis in rheumatoid arthritis (INIRA): whole-body synovial uptake of a 99mTc-labelled RGD peptide is highly correlated with power Doppler ultrasound. Ann Rheum Dis 2020;79, supplement 1:110.